Saturday, July 12, 2008

Pituitary Clinical Trials

From NIH (July 12, 2008)

1
Recruiting
Prevalence of Pituitary Incidentaloma in Relatives of Patients With Pituitary Adenoma
Condition:
Pituitary Adenoma
Intervention:


2
Recruiting
Pituitary Tumor Surveillance: Pathogenic Correlation
Condition:
Pituitary Tumor
Intervention:


3
Recruiting
Temozolomide in Treating Patients With Invasive Pituitary Tumors
Condition:
Brain and Central Nervous System Tumors
Interventions:
Drug: temozolomide; Procedure: DNA methylation analysis; Procedure: gene expression profiling; Procedure: laboratory biomarker analysis; Procedure: protein expression analysis; Procedure: proteomic profiling

4
Recruiting
Rosiglitazone in Treating Patients With Pituitary Tumors
Condition:
Brain and Central Nervous System Tumors
Intervention:
Drug: rosiglitazone maleate

5
Recruiting
An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
Conditions:
Abnormalities; Craniopharyngioma; Cushing's Syndrome; Endocrine Disease; Pituitary Neoplasm
Intervention:


6
Recruiting
Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities
Conditions:
Healthy; Pituitary Disease; Thyroid Disease
Intervention:
Drug: TRH (Thyrotropin Releasing Hormone)

7
Recruiting
Assessment of Cardiovascular Risk Markers in Growth Hormone Deficient Patients With Nonsecreting Pituitary Adenomas
Conditions:
Growth Hormone Deficiency; Pituitary Tumor
Intervention:


8
Recruiting
Effect of Diazoxide on the Obesity Secondary to Hypothalamic-Pituitary Lesions
Conditions:
Hypothalamic-Pituitary Lesions; Craniopharyngiomas
Intervention:
Drug: DIAZOXIDE

9
Recruiting
Rosiglitazone in Treating Patients With Newly Diagnosed ACTH-Secreting Pituitary Tumor (Cushing's Disease)
Condition:
Brain and Central Nervous System Tumors
Interventions:
Drug: rosiglitazone maleate; Procedure: laboratory biomarker analysis

10
Recruiting
Evaluation of Patients With Thyroid Disorders
Conditions:
Hyperthyroidism; Hypothyroidism; Pituitary Neoplasm
Intervention:


11
Recruiting
Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency
Conditions:
Acromegaly; Growth Hormone Deficiency; Pituitary Disease
Interventions:
Drug: Somatropin; Drug: Placebo

12
Recruiting
Pituitary Functions After Traumatic Brain Injury (TBI) and/or Subarachnoid Hemorrhage (SAH)
Conditions:
Traumatic Brain Injury; Subarachnoid Hemorrhage; Hypopituitarism
Intervention:


13
Recruiting
The Treatment and Natural History of Acromegaly
Conditions:
Acromegaly; Pituitary Neoplasm
Intervention:


14
Recruiting
Lanreotide as Primary Treatment for Acromegalic Patients With Pituitary Gland Macroadenoma
Condition:
Acromegaly Associated With Pituitary Gland Macroadenoma
Intervention:
Drug: Lanreotide autogel

15
Recruiting
Does Topical Steroid Treatment Impair the Adrenal Function?
Conditions:
Hypothalamus-Pituitary-Adrenal Axis Assessement; Topical Steroid Therapy in Chronic Skin Diseases
Intervention:


16
Recruiting
Pituitary Derived-Intermedin is an Estrogen-Modulated Factor for Reducing Blood Pressure
Conditions:
Menopause; Hypertension
Intervention:
Behavioral: intermedin

17
Recruiting
Genetics of Endocrine Tumours
Condition:
Acromegaly
Intervention:


18
Recruiting
Hypothalamus-Pituitary-Adrenal Axis and Use of Mifepristone for Psychotic Depression
Condition:
Depression
Interventions:
Drug: Mifepristone; Drug: Placebo

19
Recruiting
Testosterone Gel Applied to Women With Pituitary Gland Problems
Condition:
Panhypopituitarism
Intervention:
Drug: Transdermal Testosterone gel

20
Recruiting
Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors
Conditions:
Hypopituitarism; Hypogonadism; Thyroid Dysfunction; Bone Diseases, Metabolic
Intervention:


21
Recruiting
National Cooperative Growth Study (NCGS) of Optimal Nutropin AQ and Nutropin Dosing in Pubertal Growth Hormone-Deficient (GHD) Patients
Condition:
Dwarfism, Pituitary
Intervention:


22
Recruiting
Bone Mineral Density (BMD) in Adolescents With Growth Hormone Deficiency (GHD)
Conditions:
Dwarfism, Pituitary; Turner Syndrome
Intervention:


23
Recruiting
Inter-Assay Growth Hormone and IGF-I Variability
Conditions:
Acromegaly; Growth Hormone Deficiency
Intervention:


24
Recruiting
A Phase I Study in Asthma Patients Evaluating the Effect of Doses of FlutiForm™ on the Amount, if Any, of Cortisol Produced by the Adrenal Glands
Condition:
Asthma
Interventions:
Drug: FlutiForm 250/10 ug; Drug: FlutiForm 100/10 ug; Drug: Oral Prednisone 10mg; Drug: Placebo

25
Recruiting
Study to Define Optimal IGF-1 Monitoring in Children Treated With NutropinAq
Conditions:
Turner Syndrome; Renal Insufficiency, Chronic; Pituitary Diseases; Dwarfism
Intervention:
Drug: Somatropin (rDNA origin)

26
Recruiting
Endocrine and Psychological Evaluation of Adopted Children
Condition:
Psychosocial Adjustment
Intervention:


27
Recruiting
Evaluation and Treatment of Neurosurgical Disorders
Condition:
Neurologic Disorders
Intervention:


28
Recruiting
Screening Patients With Central Nervous System Tumors for Participation in National Cancer Institute Clinical Trials
Conditions:
Brain and Central Nervous System Tumors; Lymphoma
Interventions:
Procedure: cytology specimen collection procedure; Procedure: physiologic testing

29
Recruiting
Effects of Corticotropin Releasing Hormone (CRH) on the Sleep in Patients With Hypopituitarism
Condition:
Hypopituitarism
Interventions:
Other: corticotropin releasing hormone (CRH); Other: Placebo

30
Recruiting
Effect of Calcipotriol Plus Hydrocortisone Ointment on the Adrenal Hormone Balance and Calcium Metabolism in Patients With Psoriasis Vulgaris on the Face and Skin Folds
Condition:
Psoriasis Vulgaris
Intervention:
Drug: Calcipotriol plus hydrocortisone (LEO 80190)

31
Recruiting
Testosterone-Driven Growth-Hormone (GH) Secretion in Aging Men
Condition:
Aging
Intervention:
Drug: anastrazole or dutasteride

32
Recruiting
Endocrine Studies in Health and Disease
Condition:
Endocrine Diseases
Intervention:


33
Recruiting
New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome
Condition:
Cushing Syndrome
Intervention:


34
Recruiting
Hypothalamic-Pituitary-Adrenal (HPA) Axis in Psychotic Depression
Conditions:
Psychotic Disorders; Depression; Depressive Disorder, Major
Intervention:
Drug: Mifepristone

35
Not yet recruiting
Cortisol Response to ACTH in Acute Stress
Condition:
Aortic Aneurysm, Abdominal
Intervention:
Drug: Adrenocorticotrophic hormone

36
Recruiting
Antineoplaston Therapy in Treating Patients With Brain Tumors
Condition:
Brain and Central Nervous System Tumors
Interventions:
Drug: antineoplaston A10; Drug: antineoplaston AS2-1

37
Recruiting
Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism
Conditions:
Kallmann Syndrome; Idiopathic Hypogonadotropic Hypogonadism
Intervention:
Drug: gonadotropin releasing hormone (GnRH)

38
Recruiting
Decreased Testosterone Levels in Men Over 65
Conditions:
Aging; Hypogonadism; Andropause
Interventions:
Drug: Anastrozole; Drug: Testosterone Gel

39
Recruiting
Does Inhaled Busedonide or Fluticasone Impair Adrenal Function?
Condition:
Adrenal Insufficency
Intervention:


40
Recruiting
Does Intravitreal Injection of Triamcinolone Acetonide Impairs the Adrenal Function
Condition:
Secondary Adrenal Insuffisency
Intervention:


41
Recruiting
Efficacy of Octreotide Acetate and Cabergoline in Patients With Acromegaly
Condition:
Acromegaly
Intervention:
Drug: Octreotide acetate and cabergoline

42
Recruiting
Steady-State Feedback Actions of Testosterone on Luteinizing Hormone Secretion in Young and Older Men
Condition:
Hypogonadism
Intervention:
Drug: Ketoconazole, Dexamethesone, Androgel,GnRH

43
Recruiting
Cutivate Lotion HPA Axis Pediatric Study
Condition:
Atopic Dermatitis
Intervention:
Drug: Fluticasone propionate 0.05% lotion

44
Recruiting
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
Conditions:
Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm
Intervention:


45
Not yet recruiting
Influence of Administration Route of Testosterone on Male Fertility
Condition:
Hypogonadism
Interventions:
Drug: MPP10, testosterone; Drug: Testosterone

46
Recruiting
Pulsatile GnRH in Anovulatory Infertility
Conditions:
Hypogonadotropic Hypogonadism; Amenorrhea; Kallman's Syndrome
Interventions:
Drug: GnRH; Device: Mini-infusion pump

47
Recruiting
Hydrocortisone in Patients of Out-of-Hospital Cardiac Arrest
Condition:
Heart Arrest
Intervention:
Drug: Hydrocortisone

48
Recruiting
Effect of Race on Gonadotropin Responses
Condition:
Premenopause
Interventions:
Drug: Estradiol steroid infusion; Drug: Progesterone steroid infusion

49
Not yet recruiting
Risperidone-Induced Hyperprolactinemia Treated With Bromocriptine
Conditions:
Schizophrenia; Hyperprolactinemia
Intervention:
Drug: Bromocriptin

50
Recruiting
Consequence of Lifetime Isolated Growth Hormone Deficiency
Condition:
Growth Hormone Deficiency
Intervention:
Drug: growth hormone administration for 6 months





51
Not yet recruiting
Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States
Conditions:
Acromegaly; Growth Hormone Deficiency
Intervention:


52
Recruiting
Safety and Biological Activity of C2L-OCT-01 PR in Acromegalic Patients
Condition:
Acromegaly
Interventions:
Drug: C2L-OCT-01 PR, 10 or 20 mg; Drug: C2L-OCT-01 PR, 20 mg

53
Recruiting
A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome
Condition:
Cushing's Syndrome
Intervention:
Drug: mifepristone

54
Recruiting
Physiopathology of Sodium Retention in Acromegaly
Condition:
Acromegaly
Intervention:
Drug: furosemide

55
Recruiting
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders
Conditions:
Hypogonadism; Kallmann Syndrome; Puberty, Delayed; Puberty, Precocious; Hypothalamic Amenorrhea; Anosmia
Intervention:


56
Recruiting
Characterizing Psychological Consequences of Childhood Trauma
Condition:
Major Depressive Disorder
Interventions:
Drug: DEX-CRF stimulation test; Behavioral: Psychosocial stress induction; Procedure: Brain imaging of sad mood , self-reference, reward; Behavioral: Acoustic startle

57
Recruiting
Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome
Conditions:
Cushing's Syndrome; Insulin Resistance
Intervention:
Procedure: Surgery

58
Recruiting
Exercise Amenorrhea Stress and Bone Health in Adolescents
Condition:
Healthy
Intervention:


59
Recruiting
Dexamethasone Treatment of Congenital Adrenal Hyperplasia
Condition:
Adrenal Hyperplasia, Congenital
Intervention:
Drug: dexamethasone

60
Recruiting
Leuprolide in Determining the Cause of Gonadotropin Deficiency
Condition:
Hypogonadism
Interventions:
Drug: gonadotropin releasing hormone; Drug: leuprolide

61
Not yet recruiting
Neuroendocrine Dysfunction in Traumatic Brain Injury: Correlation With Cognitive Dysfunction and Repair
Condition:
Traumatic Brain Injury
Intervention:


62
Recruiting
Study of Depression, Peptides, and Steroids in Cushing's Syndrome
Condition:
Cushing's Syndrome
Intervention:


63
Recruiting
Study of Recombinant Human Insulin-Like Growth Factor I in Patients With Severe Insulin Resistance
Conditions:
Insulin Resistance; Hyperglycemia
Intervention:
Drug: insulin-like growth factor I

64
Recruiting
Safety and Efficacy of Different Dose Levels of Pasireotide in Patients With de Novo, Persistent or Recurrent Cushing's Disease
Condition:
Cushing's Disease
Intervention:
Drug: Pasireotide

65
Recruiting
Cardiovascular Risk Factors and LCH in Adults
Condition:
Histiocytosis, Langerhans-Cell
Intervention:


66
Recruiting
Polycystic Ovary Syndrome (PCOS) and Sleep Apnea
Conditions:
Polycystic Ovary Syndrome; Obstructive Sleep Apnea
Interventions:
Device: continuous positive airway pressure (CPAP); Drug: depot leuprolide plus estrogen/progestin replacement; Drug: pioglitazone

67
Recruiting
Involvement of Endogenous Digitalis-Like Compounds in Breast Cancer
Conditions:
Breast Neoplasms; Fibrocystic Disease of Breast; Mammaplasty
Intervention:


68
Recruiting
Study of GnRH (Gonadotropin Releasing Hormone) Treatment for Idiopathic Hypogonadotropic Hypogonadism (IHH)
Condition:
Hypogonadism
Intervention:
Drug: Gonadotropin Releasing Hormone (GnRH)

69
Recruiting
Effects of Testosterone in Women With Depression
Condition:
Depression
Intervention:
Drug: Testosterone

70
Recruiting
RU-486 in the Treatment of Bipolar Depression
Condition:
Bipolar Depression
Intervention:
Drug: mifepristone (RU-486)

71
Recruiting
Prazosin to Reduce Stress-Induced Cocaine/Alcohol Craving and Relapse
Conditions:
Cocaine Dependence; Alcohol Dependence
Interventions:
Drug: Prazosin; Drug: placebo

72
Recruiting
Obesity and Weight Loss on Reproductive Function
Condition:
Obesity
Intervention:


73
Recruiting
Baselines in Reproductive Disorders
Conditions:
Amenorrhea; Hypogonadotropic Hypogonadism; Kallmann's Syndrome
Intervention:
Procedure: Frequent baseline blood sampling

74
Recruiting
rhGH and rhIGF-1 Combination Therapy in Children With Short Stature Associated With IGF-1 Deficiency
Condition:
Insulin-Like Growth Factor-1 Deficiency
Interventions:
Drug: somatropin; Drug: mecasermin and somatropin; Drug: mecasermin and somatropin; Drug: mecasermin and somatropin

75
Recruiting
Adrenal Function in Critical Illness
Condition:
Adrenal Insufficiency
Intervention:


76
Recruiting
Feasibility Study Into the Contraceptive Effect of Estetrol
Condition:
Healthy
Interventions:
Drug: estetrol; Drug: estetrol; Drug: estetrol and desogestrel; Drug: estetrol and progesterone

77
Recruiting
Ethylvinyl Acetate (EVA) Vaginal Ring Delivery System Study
Condition:
Healthy
Intervention:
Drug: Ethylvinyl Acetate (EVA) Vaginal Ring Delivery System

78
Recruiting
Guanfacine to Reduce Stress-Induced Cocaine/Alcohol Craving and Relapse
Conditions:
Cocaine Dependent; Alcohol Dependent
Interventions:
Drug: Guanfacine; Drug: Placebo

79
Recruiting
Pelvic Pain in Women With Endometriosis
Conditions:
Endometriosis; Pelvic Pain; Healthy; Tubal Ligation
Intervention:


80
Not yet recruiting
FHA: Metabolism and Stress Reactivity
Conditions:
Anovulation; FHA; Eumenorrhea
Intervention:


81
Recruiting
The Effect of Ethanol on Overnight Glucose Regulation in Type 2
Condition:
Type 2 Diabetes, Insulin Requiring
Interventions:
Other: oral ethanol, overnight; Other: IV ethanol; Other: soda water; Other: soda water

82
Recruiting
Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion
Condition:
Cushing's Syndrome
Intervention:
Drug: Mifepristone

83
Recruiting
Dexamethasone to Prevent Oral Chronic Graft-Versus-Host Disease
Condition:
Graft vs Host Disease
Intervention:
Drug: Dexamethasone 0.01% Solution

84
Recruiting
Effect of Lithium Carbonate on Low-Dose Radioiodine Therapy in Early Thyroid Cancer
Conditions:
Thyroid Cancer; Differentiated Thyroid Carcinoma
Intervention:
Drug: Lithium Carbonate

85
Recruiting
Sex Differences in Progesterone Effects on Responses to Stress and Drug Cues
Condition:
Cocaine Dependence
Interventions:
Drug: Progesterone; Drug: Placebo

86
Recruiting
Measurement of Outcome of Surgical Treatment in Patients With Acromegaly
Condition:
Acromegaly
Intervention:


87
Recruiting
Glucose Tolerance in Acromegaly: The Influence of GH-Excess on Glucose Metabolism and Insulin Resistance
Conditions:
Acromegaly; Diabetes; Insulin Resistance; Impaired Glucose Tolerance
Intervention:


88
Recruiting
Baseline Sexual Function, Cognitive Function, Body Composition and Muscle Parameters and Pharmacokinetics of Transdermal Testosterone Gel in Women With Hypopituitarism
Condition:
Panhypopituitarism
Intervention:
Drug: Transdermal Testosterone Gel

89
Recruiting
Estrogen Treatment in Acromegalic Women
Condition:
Acromegaly
Intervention:
Drug: Alesse

90
Recruiting
Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
Conditions:
Growth Hormone Deficiency; Septo-Optic Dysplasia; Hypopituitarism
Intervention:
Drug: Nutropin AQ

91
Recruiting
Predictive Factors of Response to Somatostatin Analogues in Acromegalic Patients With Persistent Disease Following Surgery
Condition:
Acromegaly
Intervention:


92
Recruiting
Androgen Replacement Therapy in Women With Hypopituitarism
Condition:
Hypopituitarism
Intervention:
Drug: TheraDerm

93
Recruiting
Substrate Metabolism and Insulin Sensitivity in Patients With Hyperprolactinemia Before and After Treatment
Conditions:
Hyperprolactinemia; Insulin Resistance
Intervention:
Drug: Cabergoline

94
Not yet recruiting
Use of Somatostatin Analogue Therapy as Primary Medical Treatment of Acromegaly
Condition:
Acromegaly
Intervention:
Drug: Somatuline Autogel

95
Recruiting
Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus
Condition:
Nephrogenic Diabetes Insipidus
Interventions:
Drug: sildenafil; Drug: calcitonin; Drug: hydrochlorothiazide/amiloride; Drug: indomethacin; Drug: Placebo for sildenafil; Drug: placebo for calcitonin

96
Recruiting
Somatuline® Depot (Lanreotide) for Acromegaly Post-Marketing Observational Study
Condition:
Acromegaly
Intervention:


97
Recruiting
Endometriosis Patients Undergoing Quinagolide Treatment
Conditions:
Hyperprolactinemia; Endometriosis
Intervention:
Procedure: ENDOMETRIAL BIOPSY

98
Recruiting
Changes of Left Ventricular Mass and Cardiac Function in Patients With Active Acromegaly During Treatment With the Growth Hormone Receptor Antagonist Pegvisomant
Conditions:
Acromegaly; Heart Failure; Hypertrophy, Left Ventricular
Intervention:
Drug: pegvisomant

99
Not yet recruiting
Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia
Conditions:
Hyperprolactinemia; Weight Gain; Dyslipidemia
Intervention:
Drug: Abilify (aripiprazole)

100
Not yet recruiting
Open Label Study to Assess the Efficacy of an Extended Injection Interval Schedule of Lanreotide Autogel 120 mg in Acromegalic Subjects Who Are Biochemically Controlled on Long Term Treatment With Octreotide LAR 10 or 20 mg
Condition:
Acromegaly
Intervention:
Drug: Lanreotide Autogel 120 mg





101
Recruiting
Open Label Extension Study Evaluating Safety and Biological Activity of C2L-OCT-01 PR in Acromegalic Patients
Condition:
Acromegaly
Intervention:
Drug: C2L-OCT-01 PR 30 mg

102
Recruiting
Ultrasound Guided Sandostatin LAR Injection in Acromegaly
Condition:
Acromegaly
Interventions:
Drug: Sandostatin LAR; Drug: Sandostatin LAR

103
Recruiting
Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment
Conditions:
Acromegaly; Growth Hormone; Insulin Resistance
Intervention:
Procedure: Transsphenoidal adenomectomy

104
Recruiting
Co-Treatment With Pegvisomant and a Somatostatin Analogue (SA) in SA-Responsive Acromegalic Patients
Conditions:
Acromegaly; Insulin Resistance; Impaired Glucose Tolerance
Interventions:
Drug: Pegvisomant; Drug: Somatostatin analog (Lanreotid or Octreotid)

105
Recruiting
Testosterone and Growth Hormone for Bone Loss in Men
Conditions:
Hypopituitarism; Hypogonadism; Growth Hormone Deficiency
Interventions:
Drug: Testosterone plus somatropin; Drug: testosterone

106
Recruiting
Safety and Efficacy of Pasireotide Long Acting Release (LAR) vs. Octreotide LAR in Patients With Active Acromegaly
Condition:
Acromegaly
Intervention:
Drug: Pasireotide