Tuesday, July 8, 2008

Cushing's Clinical Trials

From NIH (7/8/2008)

1
Recruiting
Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion
Condition:
Cushing's Syndrome
Intervention:
Drug: Mifepristone

2
Recruiting
Diagnostic Performance of Screening Tests for Cushing's Syndrome
Condition:
Cushing's Syndrome
Intervention:


3
Recruiting
A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome
Condition:
Cushing's Syndrome
Intervention:
Drug: mifepristone

4
Active, not recruiting
Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's Syndrome
Condition:
Cushing's Syndrome
Intervention:


5
Active, not recruiting
Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing Syndrome
Condition:
Cushing's Syndrome
Intervention:


6
Completed
Long Term Post Operative Follow-Up of Cushing Syndrome
Condition:
Cushing Syndrome
Intervention:


7
Recruiting
New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome
Condition:
Cushing Syndrome
Intervention:


8
Active, not recruiting
Extension Study to Assess the Safety and Efficacy of Pasireotide in Patients With Cushing's Disease
Condition:
Cushing Disease
Intervention:
Drug: Pasireotide

9
Completed
Study of Cushing's Syndrome Not Related to ACTH Production
Conditions:
Cushing's Syndrome; Healthy
Intervention:


10
Recruiting
Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome
Conditions:
Cushing's Syndrome; Insulin Resistance
Intervention:
Procedure: Surgery

11
Recruiting
Study of Depression, Peptides, and Steroids in Cushing's Syndrome
Condition:
Cushing's Syndrome
Intervention:


12
Recruiting
Safety and Efficacy of Different Dose Levels of Pasireotide in Patients With de Novo, Persistent or Recurrent Cushing's Disease
Condition:
Cushing's Disease
Intervention:
Drug: Pasireotide

13
Completed
Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome
Condition:
Cushing's Syndrome
Intervention:


14
Active, not recruiting
A Study to Assess SOM230 in Patients With Pituitary Cushing's Disease
Condition:
Cushing's Syndrome
Intervention:
Drug: SOM230 s.c.

15
Completed
Cognition, Steroids, and Imaging in Cushings Disease
Condition:
Cushing Syndrome
Intervention:


16
Completed
Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency
Conditions:
Adrenal Gland Hyperfunction; Adrenal Gland Hypofunction; Cushing's Syndrome; Healthy
Intervention:
Drug: Ovine Corticotropin-Releasing Hormone (oCRH)

17
Recruiting
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
Conditions:
Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm
Intervention:


18
Recruiting
An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
Conditions:
Abnormalities; Craniopharyngioma; Cushing's Syndrome; Endocrine Disease; Pituitary Neoplasm
Intervention:


19
Recruiting
Rosiglitazone in Treating Patients With Newly Diagnosed ACTH-Secreting Pituitary Tumor (Cushing's Disease)
Condition:
Brain and Central Nervous System Tumors
Interventions:
Drug: rosiglitazone maleate; Procedure: laboratory biomarker analysis

20
Recruiting
Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma
Conditions:
Adrenocortical Carcinoma; Cushing's Syndrome
Intervention:


21
Completed
Heart Disease Risk Factors in Major Depression
Conditions:
Adrenal Gland Hyperfunction; Cardiovascular Disease; Involutional Depression
Intervention:


22
Recruiting
Adrenal Tumors - Pathogenesis and Therapy
Conditions:
Adrenal Tumors; Adrenocortical Carcinoma; Cushing Syndrome; Conn Syndrome; Pheochromocytoma
Intervention:


23
Recruiting
Adolescence, Puberty, and Emotion Regulation
Conditions:
Mood Disorder; Neurobehavioral Manifestation; Healthy
Intervention:


24
Completed
Dynamics of Leptin and Endocrine Function
Conditions:
Healthy; Involutional Depression
Intervention:


25
Recruiting
Study of Adrenal Gland Tumors
Condition:
Adrenal Gland Neoplasm
Intervention:


26
Completed
Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure
Condition:
Addison Syndrome
Intervention:
Drug: hydrocortisone substitution therapy versus withdrawal

27
Recruiting
Rosiglitazone in Treating Patients With Pituitary Tumors
Condition:
Brain and Central Nervous System Tumors
Intervention:
Drug: rosiglitazone maleate

28
Recruiting
Examination of Brain Serotonin Receptors in Patients With Mood Disorders
Condition:
Mood Disorder
Intervention:


29
Completed
Pharmacist Assisted Medication Program Empowering Regulation of Diabetes
Condition:
Diabetes Mellitus, Type 2
Interventions:
Other: Pharmacist collaboration in diabetes care; Other: Usual care

30
Recruiting
A Study of rhuMAb IFNalpha in Adults With Systemic Lupus Erythematosus
Condition:
Systemic Lupus Erythematosus
Intervention:
Drug: rhuMAb IFNalpha

31
Recruiting
Etanercept for the Treatment of Lupus Nephritis
Condition:
Lupus Nephritis
Interventions:
Drug: Etanercept; Drug: Lupus Treatment