A Virginia neurologist thinks that Pio Pico--the last Mexican governor of California, whose Pico House Hotel still stands near Olvera Street--suffered from acromegaly, complicated by a benign tumor of the pituitary gland. That made cartilage and soft tissue in his face grow large and disproportionate.
The Los Angeles Times headline reads: What made Pio Pico so feo? It's a bit harsh, but yeah. He's no Antonio Banderas. And he don't look a bit like his brother Andres, below.
Dr. Ivan S. Login (the neurologist) says "When you see one person who's got that [acromegaly], you recognize it forever." Well, yes, and I'm sure the doctor knows his stuff. But it's also true that if you're holding a hammer, everything starts to look like a nail.