Wednesday, August 6, 2008

Oncology News: Malignant Gliomas in Adults

Oncology News: Malignant Gliomas in Adults:

"Corticosteroids such as dexamethasone are frequently used to treat peritumoral edema. Cushing's syndrome and corticosteroid myopathy may develop in patients who require prolonged treatment with high doses of corticosteroids.

Patients with brain tumors who receive corticosteroids are at increased risk for Pneumocystis jiroveci pneumonitis, and prophylactic antibiotic therapy should be considered,49 although a recent meta-analysis did not show a benefit from this approach.51 As the rate of survival among patients with malignant glioma improves, long-term complications from treatment with corticosteroids, including osteoporosis and compression fractures, are becoming increasingly evident, and preventive measures, such as treatment with vitamin D, calcium supplements, and bisphosphonates, should be considered.

Novel therapies such as corticotropin-releasing factor, bevacizumab (a humanized VEGF monoclonal antibody), and VEGFR inhibitors decrease peritumoral edema and may reduce the need for corticosteroids."