Pituitary Clinical Trials

From NIH (July 12, 2008)

1		Recruiting		Prevalence of Pituitary Incidentaloma in Relatives of Patients With Pituitary Adenoma
				Condition:		Pituitary Adenoma
				Intervention:
2		Recruiting		Pituitary Tumor Surveillance: Pathogenic Correlation
				Condition:		Pituitary Tumor
				Intervention:
3		Recruiting		Temozolomide in Treating Patients With Invasive Pituitary Tumors
				Condition:		Brain and Central Nervous System Tumors
				Interventions:		Drug: temozolomide; Procedure: DNA methylation analysis; Procedure: gene expression profiling; Procedure: laboratory biomarker analysis; Procedure: protein expression analysis; Procedure: proteomic profiling
4		Recruiting		Rosiglitazone in Treating Patients With Pituitary Tumors
				Condition:		Brain and Central Nervous System Tumors
				Intervention:		Drug: rosiglitazone maleate
5		Recruiting		An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
				Conditions:		Abnormalities; Craniopharyngioma; Cushing's Syndrome; Endocrine Disease; Pituitary Neoplasm
				Intervention:
6		Recruiting		Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities
				Conditions:		Healthy; Pituitary Disease; Thyroid Disease
				Intervention:		Drug: TRH (Thyrotropin Releasing Hormone)
7		Recruiting		Assessment of Cardiovascular Risk Markers in Growth Hormone Deficient Patients With Nonsecreting Pituitary Adenomas
				Conditions:		Growth Hormone Deficiency; Pituitary Tumor
				Intervention:
8		Recruiting		Effect of Diazoxide on the Obesity Secondary to Hypothalamic-Pituitary Lesions
				Conditions:		Hypothalamic-Pituitary Lesions; Craniopharyngiomas
				Intervention:		Drug: DIAZOXIDE
9		Recruiting		Rosiglitazone in Treating Patients With Newly Diagnosed ACTH-Secreting Pituitary Tumor (Cushing's Disease)
				Condition:		Brain and Central Nervous System Tumors
				Interventions:		Drug: rosiglitazone maleate; Procedure: laboratory biomarker analysis
10		Recruiting		Evaluation of Patients With Thyroid Disorders
				Conditions:		Hyperthyroidism; Hypothyroidism; Pituitary Neoplasm
				Intervention:
11		Recruiting		Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency
				Conditions:		Acromegaly; Growth Hormone Deficiency; Pituitary Disease
				Interventions:		Drug: Somatropin; Drug: Placebo
12		Recruiting		Pituitary Functions After Traumatic Brain Injury (TBI) and/or Subarachnoid Hemorrhage (SAH)
				Conditions:		Traumatic Brain Injury; Subarachnoid Hemorrhage; Hypopituitarism
				Intervention:
13		Recruiting		The Treatment and Natural History of Acromegaly
				Conditions:		Acromegaly; Pituitary Neoplasm
				Intervention:
14		Recruiting		Lanreotide as Primary Treatment for Acromegalic Patients With Pituitary Gland Macroadenoma
				Condition:		Acromegaly Associated With Pituitary Gland Macroadenoma
				Intervention:		Drug: Lanreotide autogel
15		Recruiting		Does Topical Steroid Treatment Impair the Adrenal Function?
				Conditions:		Hypothalamus-Pituitary-Adrenal Axis Assessement; Topical Steroid Therapy in Chronic Skin Diseases
				Intervention:
16		Recruiting		Pituitary Derived-Intermedin is an Estrogen-Modulated Factor for Reducing Blood Pressure
				Conditions:		Menopause; Hypertension
				Intervention:		Behavioral: intermedin
17		Recruiting		Genetics of Endocrine Tumours
				Condition:		Acromegaly
				Intervention:
18		Recruiting		Hypothalamus-Pituitary-Adrenal Axis and Use of Mifepristone for Psychotic Depression
				Condition:		Depression
				Interventions:		Drug: Mifepristone; Drug: Placebo
19		Recruiting		Testosterone Gel Applied to Women With Pituitary Gland Problems
				Condition:		Panhypopituitarism
				Intervention:		Drug: Transdermal Testosterone gel
20		Recruiting		Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors
				Conditions:		Hypopituitarism; Hypogonadism; Thyroid Dysfunction; Bone Diseases, Metabolic
				Intervention:
21		Recruiting		National Cooperative Growth Study (NCGS) of Optimal Nutropin AQ and Nutropin Dosing in Pubertal Growth Hormone-Deficient (GHD) Patients
				Condition:		Dwarfism, Pituitary
				Intervention:
22		Recruiting		Bone Mineral Density (BMD) in Adolescents With Growth Hormone Deficiency (GHD)
				Conditions:		Dwarfism, Pituitary; Turner Syndrome
				Intervention:
23		Recruiting		Inter-Assay Growth Hormone and IGF-I Variability
				Conditions:		Acromegaly; Growth Hormone Deficiency
				Intervention:
24		Recruiting		A Phase I Study in Asthma Patients Evaluating the Effect of Doses of FlutiForm™ on the Amount, if Any, of Cortisol Produced by the Adrenal Glands
				Condition:		Asthma
				Interventions:		Drug: FlutiForm 250/10 ug; Drug: FlutiForm 100/10 ug; Drug: Oral Prednisone 10mg; Drug: Placebo
25		Recruiting		Study to Define Optimal IGF-1 Monitoring in Children Treated With NutropinAq
				Conditions:		Turner Syndrome; Renal Insufficiency, Chronic; Pituitary Diseases; Dwarfism
				Intervention:		Drug: Somatropin (rDNA origin)
26		Recruiting		Endocrine and Psychological Evaluation of Adopted Children
				Condition:		Psychosocial Adjustment
				Intervention:
27		Recruiting		Evaluation and Treatment of Neurosurgical Disorders
				Condition:		Neurologic Disorders
				Intervention:
28		Recruiting		Screening Patients With Central Nervous System Tumors for Participation in National Cancer Institute Clinical Trials
				Conditions:		Brain and Central Nervous System Tumors; Lymphoma
				Interventions:		Procedure: cytology specimen collection procedure; Procedure: physiologic testing
29		Recruiting		Effects of Corticotropin Releasing Hormone (CRH) on the Sleep in Patients With Hypopituitarism
				Condition:		Hypopituitarism
				Interventions:		Other: corticotropin releasing hormone (CRH); Other: Placebo
30		Recruiting		Effect of Calcipotriol Plus Hydrocortisone Ointment on the Adrenal Hormone Balance and Calcium Metabolism in Patients With Psoriasis Vulgaris on the Face and Skin Folds
				Condition:		Psoriasis Vulgaris
				Intervention:		Drug: Calcipotriol plus hydrocortisone (LEO 80190)
31		Recruiting		Testosterone-Driven Growth-Hormone (GH) Secretion in Aging Men
				Condition:		Aging
				Intervention:		Drug: anastrazole or dutasteride
32		Recruiting		Endocrine Studies in Health and Disease
				Condition:		Endocrine Diseases
				Intervention:
33		Recruiting		New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome
				Condition:		Cushing Syndrome
				Intervention:
34		Recruiting		Hypothalamic-Pituitary-Adrenal (HPA) Axis in Psychotic Depression
				Conditions:		Psychotic Disorders; Depression; Depressive Disorder, Major
				Intervention:		Drug: Mifepristone
35		Not yet recruiting		Cortisol Response to ACTH in Acute Stress
				Condition:		Aortic Aneurysm, Abdominal
				Intervention:		Drug: Adrenocorticotrophic hormone
36		Recruiting		Antineoplaston Therapy in Treating Patients With Brain Tumors
				Condition:		Brain and Central Nervous System Tumors
				Interventions:		Drug: antineoplaston A10; Drug: antineoplaston AS2-1
37		Recruiting		Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism
				Conditions:		Kallmann Syndrome; Idiopathic Hypogonadotropic Hypogonadism
				Intervention:		Drug: gonadotropin releasing hormone (GnRH)
38		Recruiting		Decreased Testosterone Levels in Men Over 65
				Conditions:		Aging; Hypogonadism; Andropause
				Interventions:		Drug: Anastrozole; Drug: Testosterone Gel
39		Recruiting		Does Inhaled Busedonide or Fluticasone Impair Adrenal Function?
				Condition:		Adrenal Insufficency
				Intervention:
40		Recruiting		Does Intravitreal Injection of Triamcinolone Acetonide Impairs the Adrenal Function
				Condition:		Secondary Adrenal Insuffisency
				Intervention:
41		Recruiting		Efficacy of Octreotide Acetate and Cabergoline in Patients With Acromegaly
				Condition:		Acromegaly
				Intervention:		Drug: Octreotide acetate and cabergoline
42		Recruiting		Steady-State Feedback Actions of Testosterone on Luteinizing Hormone Secretion in Young and Older Men
				Condition:		Hypogonadism
				Intervention:		Drug: Ketoconazole, Dexamethesone, Androgel,GnRH
43		Recruiting		Cutivate Lotion HPA Axis Pediatric Study
				Condition:		Atopic Dermatitis
				Intervention:		Drug: Fluticasone propionate 0.05% lotion
44		Recruiting		Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
				Conditions:		Cushing's Syndrome; Hereditary Neoplastic Syndrome; Lentigo; Neoplasm; Testicular Neoplasm
				Intervention:
45		Not yet recruiting		Influence of Administration Route of Testosterone on Male Fertility
				Condition:		Hypogonadism
				Interventions:		Drug: MPP10, testosterone; Drug: Testosterone
46		Recruiting		Pulsatile GnRH in Anovulatory Infertility
				Conditions:		Hypogonadotropic Hypogonadism; Amenorrhea; Kallman's Syndrome
				Interventions:		Drug: GnRH; Device: Mini-infusion pump
47		Recruiting		Hydrocortisone in Patients of Out-of-Hospital Cardiac Arrest
				Condition:		Heart Arrest
				Intervention:		Drug: Hydrocortisone
48		Recruiting		Effect of Race on Gonadotropin Responses
				Condition:		Premenopause
				Interventions:		Drug: Estradiol steroid infusion; Drug: Progesterone steroid infusion
49		Not yet recruiting		Risperidone-Induced Hyperprolactinemia Treated With Bromocriptine
				Conditions:		Schizophrenia; Hyperprolactinemia
				Intervention:		Drug: Bromocriptin
50		Recruiting		Consequence of Lifetime Isolated Growth Hormone Deficiency
				Condition:		Growth Hormone Deficiency
				Intervention:		Drug: growth hormone administration for 6 months

51		Not yet recruiting		Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States
				Conditions:		Acromegaly; Growth Hormone Deficiency
				Intervention:
52		Recruiting		Safety and Biological Activity of C2L-OCT-01 PR in Acromegalic Patients
				Condition:		Acromegaly
				Interventions:		Drug: C2L-OCT-01 PR, 10 or 20 mg; Drug: C2L-OCT-01 PR, 20 mg
53		Recruiting		A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome
				Condition:		Cushing's Syndrome
				Intervention:		Drug: mifepristone
54		Recruiting		Physiopathology of Sodium Retention in Acromegaly
				Condition:		Acromegaly
				Intervention:		Drug: furosemide
55		Recruiting		Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders
				Conditions:		Hypogonadism; Kallmann Syndrome; Puberty, Delayed; Puberty, Precocious; Hypothalamic Amenorrhea; Anosmia
				Intervention:
56		Recruiting		Characterizing Psychological Consequences of Childhood Trauma
				Condition:		Major Depressive Disorder
				Interventions:		Drug: DEX-CRF stimulation test; Behavioral: Psychosocial stress induction; Procedure: Brain imaging of sad mood , self-reference, reward; Behavioral: Acoustic startle
57		Recruiting		Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome
				Conditions:		Cushing's Syndrome; Insulin Resistance
				Intervention:		Procedure: Surgery
58		Recruiting		Exercise Amenorrhea Stress and Bone Health in Adolescents
				Condition:		Healthy
				Intervention:
59		Recruiting		Dexamethasone Treatment of Congenital Adrenal Hyperplasia
				Condition:		Adrenal Hyperplasia, Congenital
				Intervention:		Drug: dexamethasone
60		Recruiting		Leuprolide in Determining the Cause of Gonadotropin Deficiency
				Condition:		Hypogonadism
				Interventions:		Drug: gonadotropin releasing hormone; Drug: leuprolide
61		Not yet recruiting		Neuroendocrine Dysfunction in Traumatic Brain Injury: Correlation With Cognitive Dysfunction and Repair
				Condition:		Traumatic Brain Injury
				Intervention:
62		Recruiting		Study of Depression, Peptides, and Steroids in Cushing's Syndrome
				Condition:		Cushing's Syndrome
				Intervention:
63		Recruiting		Study of Recombinant Human Insulin-Like Growth Factor I in Patients With Severe Insulin Resistance
				Conditions:		Insulin Resistance; Hyperglycemia
				Intervention:		Drug: insulin-like growth factor I
64		Recruiting		Safety and Efficacy of Different Dose Levels of Pasireotide in Patients With de Novo, Persistent or Recurrent Cushing's Disease
				Condition:		Cushing's Disease
				Intervention:		Drug: Pasireotide
65		Recruiting		Cardiovascular Risk Factors and LCH in Adults
				Condition:		Histiocytosis, Langerhans-Cell
				Intervention:
66		Recruiting		Polycystic Ovary Syndrome (PCOS) and Sleep Apnea
				Conditions:		Polycystic Ovary Syndrome; Obstructive Sleep Apnea
				Interventions:		Device: continuous positive airway pressure (CPAP); Drug: depot leuprolide plus estrogen/progestin replacement; Drug: pioglitazone
67		Recruiting		Involvement of Endogenous Digitalis-Like Compounds in Breast Cancer
				Conditions:		Breast Neoplasms; Fibrocystic Disease of Breast; Mammaplasty
				Intervention:
68		Recruiting		Study of GnRH (Gonadotropin Releasing Hormone) Treatment for Idiopathic Hypogonadotropic Hypogonadism (IHH)
				Condition:		Hypogonadism
				Intervention:		Drug: Gonadotropin Releasing Hormone (GnRH)
69		Recruiting		Effects of Testosterone in Women With Depression
				Condition:		Depression
				Intervention:		Drug: Testosterone
70		Recruiting		RU-486 in the Treatment of Bipolar Depression
				Condition:		Bipolar Depression
				Intervention:		Drug: mifepristone (RU-486)
71		Recruiting		Prazosin to Reduce Stress-Induced Cocaine/Alcohol Craving and Relapse
				Conditions:		Cocaine Dependence; Alcohol Dependence
				Interventions:		Drug: Prazosin; Drug: placebo
72		Recruiting		Obesity and Weight Loss on Reproductive Function
				Condition:		Obesity
				Intervention:
73		Recruiting		Baselines in Reproductive Disorders
				Conditions:		Amenorrhea; Hypogonadotropic Hypogonadism; Kallmann's Syndrome
				Intervention:		Procedure: Frequent baseline blood sampling
74		Recruiting		rhGH and rhIGF-1 Combination Therapy in Children With Short Stature Associated With IGF-1 Deficiency
				Condition:		Insulin-Like Growth Factor-1 Deficiency
				Interventions:		Drug: somatropin; Drug: mecasermin and somatropin; Drug: mecasermin and somatropin; Drug: mecasermin and somatropin
75		Recruiting		Adrenal Function in Critical Illness
				Condition:		Adrenal Insufficiency
				Intervention:
76		Recruiting		Feasibility Study Into the Contraceptive Effect of Estetrol
				Condition:		Healthy
				Interventions:		Drug: estetrol; Drug: estetrol; Drug: estetrol and desogestrel; Drug: estetrol and progesterone
77		Recruiting		Ethylvinyl Acetate (EVA) Vaginal Ring Delivery System Study
				Condition:		Healthy
				Intervention:		Drug: Ethylvinyl Acetate (EVA) Vaginal Ring Delivery System
78		Recruiting		Guanfacine to Reduce Stress-Induced Cocaine/Alcohol Craving and Relapse
				Conditions:		Cocaine Dependent; Alcohol Dependent
				Interventions:		Drug: Guanfacine; Drug: Placebo
79		Recruiting		Pelvic Pain in Women With Endometriosis
				Conditions:		Endometriosis; Pelvic Pain; Healthy; Tubal Ligation
				Intervention:
80		Not yet recruiting		FHA: Metabolism and Stress Reactivity
				Conditions:		Anovulation; FHA; Eumenorrhea
				Intervention:
81		Recruiting		The Effect of Ethanol on Overnight Glucose Regulation in Type 2
				Condition:		Type 2 Diabetes, Insulin Requiring
				Interventions:		Other: oral ethanol, overnight; Other: IV ethanol; Other: soda water; Other: soda water
82		Recruiting		Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion
				Condition:		Cushing's Syndrome
				Intervention:		Drug: Mifepristone
83		Recruiting		Dexamethasone to Prevent Oral Chronic Graft-Versus-Host Disease
				Condition:		Graft vs Host Disease
				Intervention:		Drug: Dexamethasone 0.01% Solution
84		Recruiting		Effect of Lithium Carbonate on Low-Dose Radioiodine Therapy in Early Thyroid Cancer
				Conditions:		Thyroid Cancer; Differentiated Thyroid Carcinoma
				Intervention:		Drug: Lithium Carbonate
85		Recruiting		Sex Differences in Progesterone Effects on Responses to Stress and Drug Cues
				Condition:		Cocaine Dependence
				Interventions:		Drug: Progesterone; Drug: Placebo
86		Recruiting		Measurement of Outcome of Surgical Treatment in Patients With Acromegaly
				Condition:		Acromegaly
				Intervention:
87		Recruiting		Glucose Tolerance in Acromegaly: The Influence of GH-Excess on Glucose Metabolism and Insulin Resistance
				Conditions:		Acromegaly; Diabetes; Insulin Resistance; Impaired Glucose Tolerance
				Intervention:
88		Recruiting		Baseline Sexual Function, Cognitive Function, Body Composition and Muscle Parameters and Pharmacokinetics of Transdermal Testosterone Gel in Women With Hypopituitarism
				Condition:		Panhypopituitarism
				Intervention:		Drug: Transdermal Testosterone Gel
89		Recruiting		Estrogen Treatment in Acromegalic Women
				Condition:		Acromegaly
				Intervention:		Drug: Alesse
90		Recruiting		Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
				Conditions:		Growth Hormone Deficiency; Septo-Optic Dysplasia; Hypopituitarism
				Intervention:		Drug: Nutropin AQ
91		Recruiting		Predictive Factors of Response to Somatostatin Analogues in Acromegalic Patients With Persistent Disease Following Surgery
				Condition:		Acromegaly
				Intervention:
92		Recruiting		Androgen Replacement Therapy in Women With Hypopituitarism
				Condition:		Hypopituitarism
				Intervention:		Drug: TheraDerm
93		Recruiting		Substrate Metabolism and Insulin Sensitivity in Patients With Hyperprolactinemia Before and After Treatment
				Conditions:		Hyperprolactinemia; Insulin Resistance
				Intervention:		Drug: Cabergoline
94		Not yet recruiting		Use of Somatostatin Analogue Therapy as Primary Medical Treatment of Acromegaly
				Condition:		Acromegaly
				Intervention:		Drug: Somatuline Autogel
95		Recruiting		Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus
				Condition:		Nephrogenic Diabetes Insipidus
				Interventions:		Drug: sildenafil; Drug: calcitonin; Drug: hydrochlorothiazide/amiloride; Drug: indomethacin; Drug: Placebo for sildenafil; Drug: placebo for calcitonin
96		Recruiting		Somatuline® Depot (Lanreotide) for Acromegaly Post-Marketing Observational Study
				Condition:		Acromegaly
				Intervention:
97		Recruiting		Endometriosis Patients Undergoing Quinagolide Treatment
				Conditions:		Hyperprolactinemia; Endometriosis
				Intervention:		Procedure: ENDOMETRIAL BIOPSY
98		Recruiting		Changes of Left Ventricular Mass and Cardiac Function in Patients With Active Acromegaly During Treatment With the Growth Hormone Receptor Antagonist Pegvisomant
				Conditions:		Acromegaly; Heart Failure; Hypertrophy, Left Ventricular
				Intervention:		Drug: pegvisomant
99		Not yet recruiting		Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia
				Conditions:		Hyperprolactinemia; Weight Gain; Dyslipidemia
				Intervention:		Drug: Abilify (aripiprazole)
100		Not yet recruiting		Open Label Study to Assess the Efficacy of an Extended Injection Interval Schedule of Lanreotide Autogel 120 mg in Acromegalic Subjects Who Are Biochemically Controlled on Long Term Treatment With Octreotide LAR 10 or 20 mg
				Condition:		Acromegaly
				Intervention:		Drug: Lanreotide Autogel 120 mg

101		Recruiting		Open Label Extension Study Evaluating Safety and Biological Activity of C2L-OCT-01 PR in Acromegalic Patients
				Condition:		Acromegaly
				Intervention:		Drug: C2L-OCT-01 PR 30 mg
102		Recruiting		Ultrasound Guided Sandostatin LAR Injection in Acromegaly
				Condition:		Acromegaly
				Interventions:		Drug: Sandostatin LAR; Drug: Sandostatin LAR
103		Recruiting		Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment
				Conditions:		Acromegaly; Growth Hormone; Insulin Resistance
				Intervention:		Procedure: Transsphenoidal adenomectomy
104		Recruiting		Co-Treatment With Pegvisomant and a Somatostatin Analogue (SA) in SA-Responsive Acromegalic Patients
				Conditions:		Acromegaly; Insulin Resistance; Impaired Glucose Tolerance
				Interventions:		Drug: Pegvisomant; Drug: Somatostatin analog (Lanreotid or Octreotid)
105		Recruiting		Testosterone and Growth Hormone for Bone Loss in Men
				Conditions:		Hypopituitarism; Hypogonadism; Growth Hormone Deficiency
				Interventions:		Drug: Testosterone plus somatropin; Drug: testosterone
106		Recruiting		Safety and Efficacy of Pasireotide Long Acting Release (LAR) vs. Octreotide LAR in Patients With Active Acromegaly
				Condition:		Acromegaly
				Intervention:		Drug: Pasireotide