Showing posts with label ovaries. Show all posts
Showing posts with label ovaries. Show all posts

Wednesday, May 2, 2012

Pituitary Hormone Deficiency in Women

The pituitary gland secretes a number of hormones that are used to regulate the function of the ovaries. For this reason a loss or a deficiency in one of the pituitary hormones can impact greatly impact women.

Treatments

A deficiency in some of the pituitary hormones can be replaced with medications. Thyroid hormone can be replaced in thyroid hormone deficiencies, adrenal deficiencies can be treated with hydrocortisone, or cortisol replacements. And if a women loses reproductive function those can be replaced with estrogen/progesterone combinations. If fertility is an issue a neuroendocrinologist may work in conjunction with reproductive endocrinologists and OB/GYN to help fertility induction.

Oral Contraceptive Use

Oral contraceptives are often used in women who are not having normal cycles as a result of their neuroendocrine disease. These women are often also estrogen deficient, which is not good for their bones or women’s health in general. Oral contraceptives or other forms of estrogen and progesterone are often used to replace these hormones and help regulate the cycle if a women is of pre-menopausal age. These hormones are usually replaced until the age in which a woman would normally go through menopause when the medications would be stopped.

From http://www.brighamandwomens.org/Departments_and_Services/
neurology/services/WomensNeurology/WomensNeuroendocrine/hormonedeficienciesinwomen.aspx

Monday, March 14, 2011

Cushing's Syndrome due to a Pancreatic Neuroendocrine Tumor Metastatic to the Ovaries

Summary

We report the case of a 36-year-old woman with Cushing's syndrome caused by a malignant unresectable neuroendocrine carcinoma of the pancreas that developed bilateral ovarian metastases 7 years after diagnosis.

In November 2001, because of abdominal pain and jaundice, the patient underwent radiological investigations and exploratory laparotomy that demonstrated the presence of a 3-cm mass of the head of the pancreas, infiltrating the superior mesenteric vein, associated with enlargement of multiple abdominal lymph nodes and with a liver nodule. Histological examination of one lymph node and of the liver nodule demonstrated the presence of metastases from a well-differentiated neuroendocrine carcinoma showing corticotropin immunoreactivity.

A few months later, the patient started to show the clinical symptoms of Cushing's syndrome and underwent steroid-blocking ketoconazole therapy. The clinical endocrine picture was controlled until the end of 2008, when the endocrine symptoms of the Cushing's syndrome worsened and bilateral ovarian tumors appeared. Hysteroannexectomy was performed and ovarian tumors were found to be metastases from a well-differentiated neuroendocrine carcinoma with morphological and immunohistochemical features overlapping those observed in 2002.

The clinical situation worsened and the patient died in November 2009. The clinical aspects and the problems in the differential diagnosis are discussed.

Affiliation

Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy, stefano.larosa@ospedale.varese.it.

Journal Details

Name: Endocrine pathology
ISSN: 1559-0097
Pages:

Links

From http://www.bioportfolio.com/resources/pmarticle/155008/Cushing-s-Syndrome-Due-To-A-Pancreatic-Neuroendocrine-Tumor-Metastatic-To-The.html