Research and Markets: Pituitary ACTH Hypersecretion (Cushing's Disease) - Pipeline Review Report, H1 2013 Edition

Research and Markets (http://www.researchandmarkets.com/
research/rdf6gm/pituitary_acth) has announced the addition of the "Pituitary ACTH Hypersecretion (Cushing's Disease) - Pipeline Review, H1 2013" report to their offering.

'Pituitary ACTH Hypersecretion (Cushing's Disease) - Pipeline Review, H2 2013', provides an overview of the indication's therapeutic pipeline. This report provides information on the therapeutic development for Pituitary ACTH Hypersecretion (Cushing's Disease), complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Pituitary ACTH Hypersecretion (Cushing's Disease).

Scope

- A snapshot of the global therapeutic scenario for Pituitary ACTH Hypersecretion (Cushing's Disease).

- A review of the Pituitary ACTH Hypersecretion (Cushing's Disease) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.

- Coverage of products based on various stages of development ranging from discovery till registration stages.

- A feature on pipeline projects on the basis of monotherapy and combined therapeutics.

- Coverage of the Pituitary ACTH Hypersecretion (Cushing's Disease) pipeline on the basis of route of administration and molecule type.

- Key discontinued pipeline projects.

- Latest news and deals relating to the products.

Companies Involved in Pituitary ACTH Hypersecretion (Cushing's Disease) Therapeutics Development

• Isis Pharmaceuticals, Inc.
• Ipsen S.A.
• Novartis AG
• HRA Pharma, SA
• Cortendo Invest AB

Drug Profiles: Product Description, Mechanism of Action and R&D Progress

• LCI-699
• mifepristone
• ISIS-GCCRRx
• Inhibitors of ACTH receptor
• ketoconazole
• Next Generation Cortisol Inhibitor
• pasireotide Long Acting Release

For more information visit http://www.researchandmarkets.com/research/rdf6gm/pituitary_acth

Read more here: http://www.heraldonline.com/2013/06/17/4952623/research-and-markets-pituitary.html#storylink=cpy

Read more here: http://www.heraldonline.com/2013/06/17/4952623/research-and-markets-pituitary.html#storylink=cpy

Healthy New Year Video Challenge

$5,000 in prizes!

 

Let’s get the new year off to a healthy start! The Office of the National Coordinator for Health Information Technology (ONC) Healthy New Year Video Challenge (#HealthIT4U2012) invites you to create a short, compelling video (up to 2 minutes in length) sharing one New Year’s resolution for improving your health or the health of a loved one, and how you will use technology to achieve your resolution. 

 
We encourage you to create videos that are creative, inspiring and instructive — share a resolution that others can relate to, and demonstrate how technology will make it easier to achieve. Your resolution can be anything health related, such as quitting smoking or drinking, eating healthier, losing weight, reducing stress, or managing a chronic condition. Videos must show how you will use information technology to achieve your resolution and how you plan to maintain it. Entries could include the following kinds of resolutions (these are just examples — be creative and craft your own resolution!):

• I will set up an online personal health record for myself (or another family member) so I can have all of my health information conveniently stored in one place.
• I will ask my doctor for a copy of my own health records — electronically if available — and help him or her to identify any important information that may be missing or need to be corrected.
• I will find an online community that helps me figure out the best ways to manage my health condition (depression, cancer, diabetes, etc.)
• I will use an electronic pedometer to help me track my physical activity and will try to take 10,000 steps per day.
• I will find an app on my smartphone to help me track my food intake so I can lose 10 pounds by my high school reunion.
• I will sign up for a text reminder program on my cell phone to help me stop smoking or remind me to take my medications on time.

The goal of the challenge is to make 2012 a healthier year by motivating and inspiring others to use health information technology to be more engaged in improving health and increasing adoption of consumer health technology.

Note: To participate, you must be a citizen or permanent resident of the United States. Team members must be at least 18, but your video can include minors under 18 as long as a parent or legal guardian signs their consent forms. For details on eligibility, review the Official Rules.

More at http://healthynewyea...v/details/about

Book: Harvey Cushing: A Life In Surgery

Harvey Cushing: A Life In Surgery

Review by Dr. Alfredo Quiñones-Hinojosa.  Dr. Alfredo Quiñones-Hinojosa (also known as "Dr. Q") is the Associate Professor of Neurosurgery, Neuroscience, Oncology and Cellular and Molecular Medicine, and the Director of the Brain Tumor Stem Cell Laboratory at Johns Hopkins University School of Medicine.

Michael Bliss, Paperback, 591 pages

Here is the first biography to appear in fifty years of Harvey Cushing, a giant of American medicine and without doubt the greatest figure in the history of brain surgery.

Drawing on new collections of intimate personal and family papers, diaries and patient records, Michael Bliss captures Cushing's professional and his personal life in remarkable detail. Bliss paints an engaging portrait of a man of ambition, boundless, driving energy, a fanatical work ethic, a penchant for self-promotion and ruthlessness, more than a touch of egotism and meanness, and an enormous appetite for life. Equally important, Bliss traces the rise of American surgery as seen through the eyes of one of its pioneers. The book describes how Cushing, working in the early years of the 20th century, developed remarkable new techniques that let surgeons open the skull, expose the brain, and attack tumors--all with a much higher rate of success than previously known. Indeed, Cushing made the miraculous in surgery an everyday event, as he and his team compiled an astonishing record of treating more than two thousand tumors.

This is the definitive Cushing biography, an epic narrative of high surgical adventure, capturing the highs and lows of an extraordinary life.

---

 

Review below by Dr. Alfredo Quiñones-Hinojosa.  Dr. Alfredo Quiñones-Hinojosa (also known as "Dr. Q") is the Associate Professor of Neurosurgery, Neuroscience, Oncology and Cellular and Molecular Medicine, and the Director of the Brain Tumor Stem Cell Laboratory at Johns Hopkins University School of Medicine.

Without the influence of Cajal and Halsted, the career of Harvey Cushing, born in 1869, might not have been possible. And without Cushing, many careers, including my own, would not exist. In this marvelous biography, Michael Bliss examines both the icon and the person. A genius with relentless ambition, Cushing was a mentor and tormentor, a perfectionist who often forgot the line between confidence and arrogance, yet ultimately he was a healer who once said that brain surgery amounts to "20 percent science, 75 percent artistry and 5 percent community benefit." Bliss vividly details Cushing's obsession with improving all aspects of surgical care, as well as clinical diagnostic methods. Cushing's life is like a great ghost story — it will haunt you long after it's over.

Pituitary Anatomy

(Book) Cushing's Disease

Series: Endocrine Updates, Vol. 31

Swearingen, Brooke; Biller, Beverly M. K. (Eds.)

1st Edition., 2011, 378 p. 33 illus., 7 in color., Hardcover

ISBN: 978-1-4614-0010-3

Not yet published. Available: August 15, 2011

In Cushing’s Disease, leading authorities in the field offer a thorough review of the pathogenesis, diagnostic algorithm and treatment options for this complex disease.   Beginning with a fascinating history of Cushing's disease that outlines its historical significance to both endocrinology and neurosurgery, the book goes onto  to cover the full range of important issues, including the molecular pathogenesis of Cushing’s,  anatomic pathology,  the diagnosis of Cushing's syndrome,  the differential of pseudo-Cushing's syndromes,  hypercortisolemia, surgical removal of the corticotroph adenoma, post-operative management and assessment of remission, radiotherapeutic options,  and the exciting developments in medical therapy.   In addition, the book also addresses  Cushing's disease in the pediatric population, given that its clinical manifestations and impact on growth can be severe;  silent corticotroph adenomas as a distinct clinical entity;  diagnosis and management of Cushing's disease during pregnancy, bilateral adrenalectomy, and, finally, the long-term psychological manifestations of hypercortisolemia.   Comprehensive and an invaluable addition the literature, Cushing’s Disease is an essential reference for enhancing diagnosis and treatment of this debilitating disorder.

 

Content Level » Professional/practitioner

Keywords » Nelson's syndrome - Pituiitary imaging - adenomas - radiation

Related subjects » Internal Medicine - Surgery

Table of contents 

Preface

 

Contributors

 

Chapter 1: Cushing's Disease: An Historical Perspective.

Chapter 2: Molecular Biology of Cushing’s Disease.

Chapter 3: Pathology of Cushing’s Disease.

Chapter 4: Clinical Diagnosis of Cushing’s Syndrome.

Chapter 5: Pseudo-Cushing’s Syndrome.

Chapter 6: Cyclical Cushing’s Disease.

Chapter 7: Differential Diagnosis of Cushing’s Syndrome.

Chapter 8: Radiologic Imaging Techniques in Cushing’s Disease.

Chapter 9: Surgical Treatment of Cushing’s Disease.

Chapter 10: Postoperative Management and Assessment of Cure.

Chapter 11: Radiation Therapy in the Management of Cushing’s Disease.

Chapter 12: Medical Management of Cushing’s Disease.

Chapter 13:  Recurrent Cushing’s Disease

Chapter 14: Diagnosis and Treatment of Pediatric Cushing’s Disease.

Chapter 15: Silent Corticotroph Adenomas.

Chapter 16: Cushing’s Syndrome in Pregnancy.

Chapter 17: Nelson’s Syndrome: Corticotroph Tumor Progression after Bilateral Adrenalectomy in Cushing’s Disease.

Chapter 18: Psychosocial Aspects of Cushing’s Disease.

Index

From http://www.springer.com/medicine/internal/book/978-1-4614-0010-3

Book explains adrenal dysfunction

Adrenal Glands

Another dysfunction

“Are You Tired and Wired?” (Hay House, $24.95, Amazon price, $16.47)

Simultaneous feelings of exhaustion and being “keyed up” characterize early adrenal dysfunction, the subject of nurse practitioner Marcelle Pick’s self-help book. The adrenal glands are responsible for providing the fight-or-flight hormones in response to stress. If they’re under-producing, that’s Addison’s disease, and if they’re overproducing, that’s Cushing’s syndrome. “But if your adrenal imbalance is less extreme — as is true for hundreds of thousands of U.S. women — your practitioner is unlikely to recognize your condition,” Pick writes. She suggests a 30-day plan to solve adrenal dysfunction, including dietary supplements, exercise, stress-reduction techniques and, the biggie, an adrenal-friendly diet with regular meal times and no processed foods.

From http://www.washingtonpost.com/national/book-explains-adrenal-dysfunction-vegan-magazine-applauds-herbivore-heroes/2011/02/24/ABKaGxV_story.html

Cushing's Syndrome and Disease: A Disorder That Often Goes Undiagnosed

Obesity, excess neck fat and the ability to easily bruise are just a few signs of this commonly overlooked condition. Often it is caused by a tumor in the adrenal gland, which may be cancerous. Nancy D. Perrier, M.D., F.A.C.S., chief of the Section of Surgical Endocrinology at MD Anderson Cancer Center, discusses this disorder and the difference between the syndrome and disease.

Guest(s): Nancy D. Perrier, M.D., F.A.C.S.

• Listen to Cushing's Syndrome and Disease: A Disorder That Often Goes Undiagnosed
• Download Cushing's Syndrome and Disease: A Disorder That Often Goes Undiagnosed on iTunes

From http://www.mdanderson.org/newsroom/cancer-newsline/cancer-newsline-topics/2011/cancer-newsline-cushing-s-syndrome-and-disease-a-disorder-that-often-goes-undiagnosed.html