From the issue entitled "Special Issue on Cushing's Syndrome, Guest Editor: David C. Aron"
The Metabolic Syndrome is a diagnosis of increasing prevalence that is noted to share multiple clinical features with Cushing’s syndrome. Several studies suggest abnormalities in the Hypothalamic-Pituitary-Adrenal axis to be associated with this disease and tissue-specific hypercortisolemia is being investigated as a possible contributing factor. More research is needed to explore the relation between cortisol and the metabolic syndrome which, if confirmed, will have major therapeutic and public health implications.
Keywords Metabolic syndrome - 11-beta hydroxysteroid dehydrogenase - Cushing’s