Monday, June 6, 2011

NIH Adrenal Clinical Trials Updated 6/6/2011

Rank Status Study
1 Recruiting Trial of Vasopressin and Epinephrine to Epinephrine Only for In-Hospital Pediatric Cardiopulmonary Resuscitation
Conditions: Cardiopulmonary Arrest;   Cardiac Arrest
Interventions: Drug: Vasopressin;   Drug: Epinephrine
2 Recruiting Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment
Condition: Adrenal Gland Hypofunction
Interventions: Procedure: adrenal insufficiency testing;   Drug: prednisone
3 Recruiting The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine
Condition: Spinal Anesthesia
Interventions: Drug: Placebo;   Drug: epinephrine 25;   Drug: Epinephrine 50;   Drug: epinephrine 100;   Drug: Epi 200
4 Recruiting SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.
Condition: Hyperaldosteronism
Intervention: Other: Ct-scan or adrenal vein sampling
5 Not yet recruiting Intranasal Injection Versus Topical Administration of Epinephrin During Endoscopic Sinus Surgery
Conditions: Hypertension;   Hypotension;   Tachycardia;   Bradycardia;   Arrhythmia
Interventions: Drug: Epinephrin (Intranasal injection);   Drug: Epinephrin (Topical administration)
6 Recruiting Adrenal Insufficiency in Septic Shock
Conditions: Septic Shock;   Acute Adrenal Insufficiency
Intervention: Drug: Corticosteroid
7 Recruiting Performance of 18F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in the Diagnosis of Indeterminate Adrenal Tumors on Conventional Imaging: A French Prospective Multicentric Study
Condition: Adrenal Gland Neoplasms
Intervention: Other: FDG-PET scan
8 Unknown  Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency
Condition: Adrenal Insufficiency
Intervention:  
9 Recruiting Adrenal Function in Critical Illness
Condition: Adrenal Insufficiency
Intervention:  
10 Recruiting Adrenal Vein Sampling International Study (AVIS Study)
Condition: Hyperaldosteronism
Intervention:  
11 Recruiting Epinephrine Inhalation Aerosol USP: For Evaluation Of Efficacy And Safety In Asthma Patients
Condition: Asthma
Interventions: Drug: Epinephrine inhalation aerosol;   Drug: Placebo;   Drug: epinephrine inhalation aerosol
12 Unknown  Adrenal Insufficiency in Critical Emergencies in Digestive Diseases
Conditions: Digestive Diseases;   Adrenal Insufficiency;   Gastrointestinal Bleeding;   Variceal Bleeding;   Acute Pancreatitis
Intervention:  
13 Not yet recruiting Prevalence Study of Adrenal Suppression After Corticosteroids During Chemotherapy.
Condition: Adrenal Suppression
Intervention: Other: Prevalence study only, no study intervention
14 Recruiting Adrenal Hyperplasia Among Young People With PCOS
Conditions: Adrenal Hyperplasia;   Polycystic Ovarian Syndrome;   Oligomenorrhea;   Obesity;   Hyperandrogenism
Intervention:  
15 Recruiting Low-Dose Epinephrine Infusion Tests in Adolescent and Pediatric Patients
Condition: Congenital Disorders
Intervention: Drug: Epinephrine
16 Recruiting Evaluation of Molecular Markers in Adrenal Tumors
Condition: Adrenal Gland Neoplasms
Intervention:  
17 Unknown  Adrenal Function After Living Kidney Donation
Conditions: Addison Disease;   Hypoaldosteronism
Intervention: Procedure: Laparoscopic hand-assisted donor nephrectomy
18 Recruiting Adrenal Tumors - Pathogenesis and Therapy
Conditions: Adrenal Tumors;   Adrenocortical Carcinoma;   Cushing Syndrome;   Conn Syndrome;   Pheochromocytoma
Intervention:  
19 Not yet recruiting A Pilot Study of F-18 Paclitaxel (FPAC) PET for Evaluating Drug Delivery of Solid Tumors in Breast, Lung, Renal, and Adrenal Cancers
Conditions: Breast Cancer;   Lung Cancer;   Renal Cancer;   Adrenal Cancer
Intervention: Drug: F-18 Paclitaxel (FPAC)
20 Not yet recruiting The Hemostatic and Hemodynamic Effects of Adrenaline During Endoscopic Sinus Surgery
Condition: Chronic Sinusitis
Interventions: Drug: 1% lidocaine with 1:100,000 adrenaline;   Drug: 1% lidocaine with 1:200,000 adrenaline

 

21 Recruiting Study of Intracameral Adrenaline for Pupil Dilation Without Topical Mydriatics in Refractive Cataract Surgery
Condition: Cataract
Intervention: Drug: adrenalin
22 Recruiting Study of Adrenal Gland Tumors
Condition: Adrenal Gland Neoplasm
Intervention:
23 Recruiting The Effects of Epinephrine in Endotoxemia in Normal Volunteers
Condition: Immune System
Interventions: Biological: Endotoxin, Lipopolysaccharide, LPS;   Biological: Endotoxin, Lipopolysaccharide, LPS /Epinephrine
24 Unknown  Does Topical Steroid Treatment Impair the Adrenal Function?
Conditions: Hypothalamus-Pituitary-Adrenal Axis Assessement;   Topical Steroid Therapy in Chronic Skin Diseases
Intervention:
25 Recruiting Combination Local Anesthetics
Condition: Perioperative Pain
Interventions: Drug: 1% Lidocaine with Epinephrine;   Drug: 0.25% Bupivacaine with epinephrine;   Drug: 1% Lidocaine + 0.25% Bupivacaine with Epinephrine;   Drug: 2% Lidocaine + 0.5% Bupivacaine with epinephrine
26 Recruiting Study Comparing Peri-articular Injection of Bupivacaine With and Without Epinephrine
Condition: Osteoarthritis
Interventions: Procedure: Peri-articular injection of marcaine/epinephrine;   Procedure: Peri-articular injection of marcaine alone
27 Not yet recruiting Gluing Lacerations Utilizing Epinephrine
Condition: Lacerations
Intervention: Drug: LET - Lidocaine Epinephrine Tetracaine
28 Recruiting Use of Local Analgesia With Epinephrine During Total Hip Arthroplasty (THA)
Condition: Arthroplasty, Replacement, Hip
Intervention: Drug: ropivacaine, physical serum and adrenalin
29 Recruiting Relative Adrenal Insufficiency in Preterm Very Low Birth Weight Infants With Shock
Condition: Adrenal Insufficiency
Intervention:
30 Unknown  Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function
Condition: Cirrhosis With Ascites
Interventions: Drug: hydrocortisone;   Drug: dextrose solution 5%
31 Recruiting Bronchiolitis, Optimal Treatment in Infants and Prognosis
Condition: Bronchiolitis
Interventions: Drug: Racemic adrenaline;   Drug: Isotonic saline
32 Recruiting RAD001 in Pheochromocytoma or Nonfunctioning Carcinoid
Conditions: Pheochromocytoma;   Extra-Adrenal Paraganglioma;   Non-functioning Carcinoid
Intervention: Drug: RAD001
33 Not yet recruiting Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q4
Condition: Type 1 Diabetes
Intervention: Drug: epinephrine
34 Recruiting Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation
Condition: Hypotension After Reperfusion in Liver Transplantation
Interventions: Drug: phenylephrine;   Drug: epinephrine;   Drug: placebo control
35 Recruiting Safety Study Evaluating the Adrenal Suppression Potential of Product 0405 in Pediatric Subjects With Atopic Dermatitis
Condition: Atopic Dermatitis
Intervention: Drug: Product 0405
36 Recruiting Merits of Continuous Paravertebral Block in the Management of Renal/Adrenal Surgery by Laparotomy
Condition: Patient Scheduled for Renal and/or Adrenal Surgery
Intervention: Procedure: Continuous Paravertebral block
37 Not yet recruiting Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome
Condition: Adrenal Tumour With Mild Hypercortisolism
Intervention: Procedure: Adrenalectomy
38 Unknown  Role of the Protein Osteoprotegerin in the Bone Health of Women With Congenital Adrenal Hyperplasia
Condition: Adrenal Hyperplasia, Congenital
Intervention:
39 Recruiting Gene Polymorphisms Influencing Steroid Synthesis and Action
Conditions: Disorders of Sex Development;   Congenital Adrenal Hyperplasia;   Congenital Adrenal Hypoplasia;   Adrenal Insufficiency;   Mineralocorticoid Deficiency;   Intersex
Intervention:
40 Recruiting Adrenal Function and Use of Intralesional Triamcinolone Acetonide 10 mg/mL (Kenalog-10) in Patients With Alopecia Areata
Condition: Alopecia Areata
Intervention: Drug: Triamcinolone Acetonide 10 mg/mL (Kenalog-10)

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