Thursday, May 5, 2011

NIH Adrenal Clinical Trials Updated 5/5/2011

Rank Status Study
1 Completed Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma
Condition: Adrenal Cortex Neoplasms
2 Completed
Has Results
Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation
Condition: Adrenal Gland Neoplasms
Intervention: Procedure: Radiofrequency ablation
3 Completed Adrenal Scans With Radioiodine-Labeled Norcholesterol (NP-59)
Conditions: Adrenal Gland Neoplasms;   Adrenal Malignancies;   Abnormal Hormonal Secretions;   Electrolytes Abnormalities
Intervention: Other: Imaging, Adrenal acans
4 Recruiting Trial of Vasopressin and Epinephrine to Epinephrine Only for In-Hospital Pediatric Cardiopulmonary Resuscitation
Conditions: Cardiopulmonary Arrest;   Cardiac Arrest
Interventions: Drug: Vasopressin;   Drug: Epinephrine
5 Completed Adrenal Suppression and Adrenal Recovery Induced by Megestrol Acetate
Condition: Adrenal Function
Intervention: Drug: megestrol acetate
6 Recruiting Test Predicting Adrenal Insufficiency in Volunteers Under Prednisone Treatment
Condition: Adrenal Gland Hypofunction
Interventions: Procedure: adrenal insufficiency testing;   Drug: prednisone
7 Recruiting The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine
Condition: Spinal Anesthesia
Interventions: Drug: Placebo;   Drug: epinephrine 25;   Drug: Epinephrine 50;   Drug: epinephrine 100;   Drug: Epi 200
8 Recruiting SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.
Condition: Hyperaldosteronism
Intervention: Other: Ct-scan or adrenal vein sampling
9 Completed Make up for the Epinephrine Autoinjector
Condition: Anaphylaxis
Intervention: Device: Epinephrine autoinjector
10 Completed Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics
Conditions: Asthma;   Bronchospasm;   Wheezing;   Shortness of Breath
Interventions: Drug: Epinephrine Inhalation Aerosol, HFA;   Drug: Epinephrine Inhalation Aerosol
11 Completed Once-Daily Oral Modified-Release Hydrocortisone in Patients With Adrenal Insufficiency
Condition: Adrenal Insufficiency
Interventions: Drug: hydrocortisone (modified release), oral tablet 20 and 5 mg;   Drug: Hydrocortisone, oral tablet, 10 mg
12 Completed Pharmacokinetics (PK) Study of Epinephrine Inhalation Aerosol in Healthy Volunteers
Condition: Asthma
Intervention: Drug: epinephrine inhalation aerosol
13 Completed ED50 and ED95 of Intrathecal Bupivacaine With or Without Epinephrine for Total Knee Replacement Arthroplasty
Conditions: Spinal Anesthesia;   Total Knee Replacement Arthroplasty
Interventions: Drug: intrathecal bupivacaine 6 mg with 100 mcg of epinephrine;   Drug: intrathecal bupivacaine 7 mg with 100 mcg of epinephrine;   Drug: intrathecal bupivacaine 8 mg with 100 mcg of epinephrine;   Drug: intrathecal bupivacaine 9 mg with 100 mcg of epinephrine;   Drug: intrathecal bupivacaine 10 mg with 100 mcg of epinephrine;   Drug: intrathecal bupivacaine 11 mg with epinephrine 100 mcg;   Drug: intrathecal bupivacaine 6 mg with 200 mcg of epinephrine;   Drug: intrathecal bupivacaine 7 mg with 200 mcg of epinephrine;   Drug: intrathecal bupivacaine 8 mg with 200 mcg of epinephrine;   Drug: intrathecal bupivacaine 9 mg with 200 mcg of epinephrine;   Drug: intrathecal bupivacaine 10 mg with 200 mcg of epinephrine;   Drug: intrathecal bupivacaine 11 mg with 200 mcg of epinephrine
14 Active, not recruiting Study of UK Adults With Congenital Adrenal Hyperplasia.
Condition: Congenital Adrenal Hyperplasia
15 Not yet recruiting Intranasal Injection Versus Topical Administration of Epinephrin During Endoscopic Sinus Surgery
Conditions: Hypertension;   Hypotension;   Tachycardia;   Bradycardia;   Arrhythmia
Interventions: Drug: Epinephrin (Intranasal injection);   Drug: Epinephrin (Topical administration)
16 Recruiting Adrenal Insufficiency in Septic Shock
Conditions: Septic Shock;   Acute Adrenal Insufficiency
Intervention: Drug: Corticosteroid
17 Recruiting Performance of 18F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in the Diagnosis of Indeterminate Adrenal Tumors on Conventional Imaging: A French Prospective Multicentric Study
Condition: Adrenal Gland Neoplasms
Intervention: Other: FDG-PET scan
18 Unknown  Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency
Condition: Adrenal Insufficiency
19 Completed Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency
Conditions: Adrenal Gland Hyperfunction;   Adrenal Gland Hypofunction;   Cushing's Syndrome;   Healthy
Intervention: Drug: Ovine Corticotropin-Releasing Hormone (oCRH)
20 Recruiting Adrenal Function in Critical Illness
Condition: Adrenal Insufficiency


Rank Status Study
21 Recruiting Study of Adrenal Gland Tumors
Condition: Adrenal Gland Neoplasm
22 Recruiting The Effects of Epinephrine in Endotoxemia in Normal Volunteers
Condition: Immune System
Interventions: Biological: Endotoxin, Lipopolysaccharide, LPS;   Biological: Endotoxin, Lipopolysaccharide, LPS /Epinephrine
23 Unknown  Does Topical Steroid Treatment Impair the Adrenal Function?
Conditions: Hypothalamus-Pituitary-Adrenal Axis Assessement;   Topical Steroid Therapy in Chronic Skin Diseases
24 Recruiting Combination Local Anesthetics
Condition: Perioperative Pain
Interventions: Drug: 1% Lidocaine with Epinephrine;   Drug: 0.25% Bupivacaine with epinephrine;   Drug: 1% Lidocaine + 0.25% Bupivacaine with Epinephrine;   Drug: 2% Lidocaine + 0.5% Bupivacaine with epinephrine
25 Recruiting Study Comparing Peri-articular Injection of Bupivacaine With and Without Epinephrine
Condition: Osteoarthritis
Interventions: Procedure: Peri-articular injection of marcaine/epinephrine;   Procedure: Peri-articular injection of marcaine alone
26 Not yet recruiting Gluing Lacerations Utilizing Epinephrine
Condition: Lacerations
Intervention: Drug: LET - Lidocaine Epinephrine Tetracaine
27 Recruiting Use of Local Analgesia With Epinephrine During Total Hip Arthroplasty (THA)
Condition: Arthroplasty, Replacement, Hip
Intervention: Drug: ropivacaine, physical serum and adrenalin
28 Recruiting Relative Adrenal Insufficiency in Preterm Very Low Birth Weight Infants With Shock
Condition: Adrenal Insufficiency
29 Unknown  Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function
Condition: Cirrhosis With Ascites
Interventions: Drug: hydrocortisone;   Drug: dextrose solution 5%
30 Recruiting Bronchiolitis, Optimal Treatment in Infants and Prognosis
Condition: Bronchiolitis
Interventions: Drug: Racemic adrenaline;   Drug: Isotonic saline
31 Recruiting RAD001 in Pheochromocytoma or Nonfunctioning Carcinoid
Conditions: Pheochromocytoma;   Extra-Adrenal Paraganglioma;   Non-functioning Carcinoid
Intervention: Drug: RAD001
32 Not yet recruiting Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q4
Condition: Type 1 Diabetes
Intervention: Drug: epinephrine
33 Recruiting Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation
Condition: Hypotension After Reperfusion in Liver Transplantation
Interventions: Drug: phenylephrine;   Drug: epinephrine;   Drug: placebo control
34 Recruiting Safety Study Evaluating the Adrenal Suppression Potential of Product 0405 in Pediatric Subjects With Atopic Dermatitis
Condition: Atopic Dermatitis
Intervention: Drug: Product 0405
35 Recruiting Merits of Continuous Paravertebral Block in the Management of Renal/Adrenal Surgery by Laparotomy
Condition: Patient Scheduled for Renal and/or Adrenal Surgery
Intervention: Procedure: Continuous Paravertebral block
36 Not yet recruiting Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome
Condition: Adrenal Tumour With Mild Hypercortisolism
Intervention: Procedure: Adrenalectomy
37 Recruiting Role of the Protein Osteoprotegerin in the Bone Health of Women With Congenital Adrenal Hyperplasia
Condition: Adrenal Hyperplasia, Congenital
38 Recruiting Gene Polymorphisms Influencing Steroid Synthesis and Action
Conditions: Disorders of Sex Development;   Congenital Adrenal Hyperplasia;   Congenital Adrenal Hypoplasia;   Adrenal Insufficiency;   Mineralocorticoid Deficiency;   Intersex
39 Recruiting Adrenal Function and Use of Intralesional Triamcinolone Acetonide 10 mg/mL (Kenalog-10) in Patients With Alopecia Areata
Condition: Alopecia Areata
Intervention: Drug: Triamcinolone Acetonide 10 mg/mL (Kenalog-10)
40 Recruiting Assessment of the Efficacy of Nebulised 3% Hypertonic Saline Among Infants Aged 6 Weeks- 24 Months With Bronchiolitis
Condition: Bronchiolitis
Interventions: Drug: L-Epinephrine and 0.9% Normal Saline;   Drug: L-Epinephrine and 3% Hypertonic Saline