Saturday, April 30, 2011

Cushing’s syndrome in pregnancy

    BMJ Case Reports   2011;  doi:10.1136/bcr.01.2011.3720

    * Rare disease

   1. Margarita Victoria B Holgado-Galicia1,
   2. Jose Donato Magno2,
   3. Czarlota Acelajado-Valdenor3,
   4. Iris Thiele Isip-Tan1,
   5. Mary Anne Lim-Abrahan1

   1. Correspondence to Dr Margarita Victoria B Holgado-Galicia,


A 22-year-old G1P0 was admitted at 26 weeks gestation for preeclampsia, hyperglycaemia and cushingoid features. Elevated 24-h urine free cortisol (UFC) and suppressed plasma adrenocorticotrophic hormone (ACTH) suggested ACTH-independent Cushing’s syndrome. Ultrasound showed left adrenal mass. She delivered preterm at 28 weeks due to severe preeclampsia and fetal distress. The infant expired after 4 days. Blood pressure was controlled after delivery and the patient was discharged on ketoconazole. Adrenalectomy was planned postpartum; however, she withdrew consent and was lost to follow-up.

A 33-year-old G1P1 presented with gestational diabetes. Pregnancy was complicated by premature delivery at 31 weeks for fetal distress. The baby improved and survived. Three months postpartum, she was evaluated for osteoporosis after sustaining a fracture from a fall. Cushingoid facies, elevated 24-h UFC, suppressed ACTH and a right adrenal mass on MRI confirmed an ACTH-independent Cushing’s syndrome. She underwent adrenalectomy and improved.