Transient Schizophrenic Reaction as a Major Symptom of Cushing's Syndrome

Jack W. Hickman, M.D., Rosser P. Atkinson, M.D., Lloyd D. Flint, M.D., and Lewis M. Hurxthal, M.D.

N Engl J Med 1961; 264:797-800 April 20, 1961

This article has no abstract; the first 100 words appear below.

MENTAL symptoms, including nervousness, irritability, mild depression and paranoid tendencies, have long been known to be associated with Cushing's syndrome. The incidence varied from 20 to 67 per cent in four series described in reports dealing with this aspect of the disorder.1 2 3 The incidence of full-blown schizophrenia is much lower. Among 35 cases of Cushing's syndrome seen at the Lahey Clinic after the original description of the condition in 1932 up to 1958, 2 patients have had mental symptoms consistent with a diagnosis of schizophrenic reaction. The following is a report of the most recent case.

Case Report

A 35-year-old . . .

Source Information

BOSTON, MASSACHUSETTS

†Formerly, fellow in internal medicine, Lahey Clinic.

‡Member, Department of Neuropsychiatry, Lahey Clinic.

§Member, Department of Urology, Lahey Clinic.

¶Member, Department of Internal Medicine, Lahey Clinic.

Read this article at http://www.nejm.org/doi/pdf/10.1056/NEJM196104202641605