This article has no abstract; the first 100 words appear below.
SINCE Cushing1 called attention to the syndrome that now bears his name, it has been recognized that the clinical manifestations of Cushing's disease are associated with adrenocortical hyper-function and the secretion of excessive amounts of cortisol. The adrenal abnormalities may be classified as nontumorous hyperplasia, benign adenoma and adrenal carcinoma.
Although the intensity of the symptoms may vary, the disorder has been characterized by an unfavorable prognosis and a progressively deteriorating course. The life expectancy2 of the untreated patient is reported as three to ten years, with an average duration of five to seven years. Patients with malignant adrenocortical tumors . . .
NEW HAVEN, CONNECTICUT
† Postdoctoral fellow, Department of Medicine, Yale University School of Medicine.
‡ Formerly, assistant professor. Department of Medicine, and, now, fellow in psychiatry, Yale University School of Medicine.